{"id":26773,"date":"2025-05-03T09:50:16","date_gmt":"2025-05-03T09:50:16","guid":{"rendered":"http:\/\/biocontroltechnologies.com\/the-phytosanitary-registration-process-assessing-effectiveness-and-efficiency-part-i-ii\/"},"modified":"2026-02-27T11:32:30","modified_gmt":"2026-02-27T10:32:30","slug":"the-phytosanitary-registration-process-assessing-effectiveness-and-efficiency-part-i-ii","status":"publish","type":"post","link":"https:\/\/biocontroltechnologies.com\/en\/2025\/05\/03\/the-phytosanitary-registration-process-assessing-effectiveness-and-efficiency-part-i-ii\/","title":{"rendered":"The Phytosanitary Registration Process: Assessing Effectiveness and Efficiency. Part I\/II"},"content":{"rendered":"<!-- Added by Post\/Page Specific Custom Code plugin, thank you for using! -->\n<style>.post-title,\n.post-title a{\n  color:#83784D !important;\n}<\/style>\n\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"26773\" class=\"elementor elementor-26773 elementor-26591\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43f5b144 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43f5b144\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e4a8e5\" data-id=\"e4a8e5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1a7a5ef7 elementor-widget elementor-widget-heading\" data-id=\"1a7a5ef7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Evaluating the Efficacy and Efficiency of Plant Protection Products:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fc894ae elementor-widget elementor-widget-heading\" data-id=\"4fc894ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Key Factors for Assessing the Impact and Performance of Biological Crop Protection Inputs.<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-36dade5f elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"36dade5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Biological plant protection products<\/strong>, also known as <strong>biopesticides<\/strong>, are transforming modern agriculture by offering effective and sustainable solutions for pest and disease control. In response to the decreasing number of approved chemical active substances and the growing regulatory pressure within the European Union, farmers are turning to alternatives that ensure crop productivity without compromising environmental health. <\/p><p>In this context, biopesticides must not only meet the requirement of being more environmentally <strong>friendly<\/strong>, but also prove their <strong>field efficacy<\/strong>, <strong>safety for both applicators and consumers<\/strong>, and <strong>economic viability<\/strong>. The key lies in rigorous evaluation\u2014ranging from their legal definition to<strong> GEP (Good Experimental Practices) trials<\/strong> and the demanding European <strong>phytosanitary registration processes<\/strong>. <\/p><p>In this blog, we explain the <strong>key aspects for evaluating the efficacy and efficiency of biological plant protection products<\/strong>, how they differ from biostimulants, the role of EPPO guidelines, and why relying on products authorized in Europe is a guarantee of proven results. A comprehensive approach to understanding how a product like <strong>T34 Biocontrol\u00ae <\/strong>is scientifically validated\u2014and how its use can be confidently integrated into modern sustainable<strong> crop protection strategies.<\/strong> <\/p><p>In this new scenario, next-generation biopesticides\u2014formulated with specific <b>microorganisms<\/b>\u2014are emerging as solid alternatives to conventional chemical treatments. However, transitioning to new management strategies can understandably raise questions: Do they really work? How is their efficacy measured? What guarantees do they offer? This post aims to answer those questions, offering a rigorous, evidence-based perspective on how biological plant protection products are scientifically evaluated.    <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-850ab5b elementor-widget elementor-widget-text-editor\" data-id=\"850ab5b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><em><strong>Important<\/strong>: This blog focuses on the<strong> evaluation of biopesticide efficacy.<\/strong> In the second part, we\u2019ll delve deeper into the approval of <strong>active substances<\/strong>, their regulation at the European level, and their role in biological plant protection products.  <\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-52d4c8d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"52d4c8d\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;waves&quot;,&quot;shape_divider_bottom&quot;:&quot;waves&quot;,&quot;shape_divider_bottom_negative&quot;:&quot;yes&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\n\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\n\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"true\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M790.5,93.1c-59.3-5.3-116.8-18-192.6-50c-29.6-12.7-76.9-31-100.5-35.9c-23.6-4.9-52.6-7.8-75.5-5.3\n\tc-10.2,1.1-22.6,1.4-50.1,7.4c-27.2,6.3-58.2,16.6-79.4,24.7c-41.3,15.9-94.9,21.9-134,22.6C72,58.2,0,25.8,0,25.8V100h1000V65.3\n\tc0,0-51.5,19.4-106.2,25.7C839.5,97,814.1,95.2,790.5,93.1z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-130d388\" data-id=\"130d388\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b0b63fe elementor-widget elementor-widget-heading\" data-id=\"b0b63fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">1. What is the difference between a biological plant protection input and a biostimulant input or product?<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2132ee9 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"2132ee9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In professional agriculture, <strong>understanding the difference between a biological plant protection product and a biostimulant<\/strong> is essential for making safe and effective decisions in crop management.<\/p><p>Both may contain similar ingredients, such as certain beneficial microorganisms, but their purpose, regulation, and mode of action are entirely different.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-9510643 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9510643\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-2f7c952\" data-id=\"2f7c952\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-87c3b2e elementor-widget-tablet__width-initial elementor-widget elementor-widget-toggle\" data-id=\"87c3b2e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1421\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1421\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-caret-right\" viewBox=\"0 0 192 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M0 384.662V127.338c0-17.818 21.543-26.741 34.142-14.142l128.662 128.662c7.81 7.81 7.81 20.474 0 28.284L34.142 398.804C21.543 411.404 0 402.48 0 384.662z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-caret-up\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M288.662 352H31.338c-17.818 0-26.741-21.543-14.142-34.142l128.662-128.662c7.81-7.81 20.474-7.81 28.284 0l128.662 128.662c12.6 12.599 3.676 34.142-14.142 34.142z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Biological Plant Protection Products<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1421\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1421\"><p>They are regulated under R<strong>egulation (EU) 1107\/2009<\/strong> and are used to <strong>protect plants against pests, diseases, or weeds.<\/strong> Their commercialization requires prior authorization based on rigorous trials that demonstrate: <\/p>\n<p>\u2013 The <strong>Efficacy <\/strong>under field conditions.<\/p>\n<p>\u2013 <strong>Safety for the applicator, the consumer, and the environment.<\/strong><\/p>\n<p>&#8211; The ability to control specific harmful organisms, supported by verified data.<\/p>\n<p>Unlike biostimulants, <strong>they can legally claim pest or disease control properties.<\/strong> This prevents confusion and protects farmers from investing in solutions whose effectiveness against pathogens <strong>is not scientifically validated<\/strong>.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-0f46def\" data-id=\"0f46def\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-052d154 elementor-widget__width-inherit elementor-widget elementor-widget-toggle\" data-id=\"052d154\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5421\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-5421\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-caret-right\" viewBox=\"0 0 192 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M0 384.662V127.338c0-17.818 21.543-26.741 34.142-14.142l128.662 128.662c7.81 7.81 7.81 20.474 0 28.284L34.142 398.804C21.543 411.404 0 402.48 0 384.662z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-caret-up\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M288.662 352H31.338c-17.818 0-26.741-21.543-14.142-34.142l128.662-128.662c7.81-7.81 20.474-7.81 28.284 0l128.662 128.662c12.6 12.599 3.676 34.142-14.142 34.142z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Biostimulants<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5421\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-5421\"><p>Regulated under <strong>Regulation (EU) 2019\/1009<\/strong>, they are classified as <strong>fertilising products<\/strong>.<br \/>Their commercialization does not require efficacy-based authorization, and their purpose is to improve:<\/p>\n<p>\u2013 Plant <strong>vigor and growth development.<\/strong><\/p>\n<p>\u2013 <strong>Nutrient uptake.<\/strong><\/p>\n<p>\u2013 Plant <strong>resilience to abiotic stress <\/strong>(such as drought or salinity).<\/p>\n<p>Unlike plant protection products, <strong>they cannot legally claim pest or disease control properties,<\/strong> even if they contain similar microorganisms. This prevents confusion and protects farmers from investing in solutions whose effectiveness against pathogens<strong> is not scientifically proven.<\/strong> <\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce72ded elementor-widget elementor-widget-heading\" data-id=\"ce72ded\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><b>Regulatory Comparison<\/b>: Plant Protection Products vs. Biostimulants<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e2390f elementor-widget elementor-widget-toggle\" data-id=\"3e2390f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-6511\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-6511\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-caret-right\" viewBox=\"0 0 192 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M0 384.662V127.338c0-17.818 21.543-26.741 34.142-14.142l128.662 128.662c7.81 7.81 7.81 20.474 0 28.284L34.142 398.804C21.543 411.404 0 402.48 0 384.662z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-caret-up\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M288.662 352H31.338c-17.818 0-26.741-21.543-14.142-34.142l128.662-128.662c7.81-7.81 20.474-7.81 28.284 0l128.662 128.662c12.6 12.599 3.676 34.142-14.142 34.142z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">EU Regulation <b>1107\/2009<\/b> \u2013 Plant Protection Products VS. EU Regulation <b>2019\/1009<\/b> \u2013 Biostimulants <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-6511\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-6511\"><table>\n<thead>\n<tr>\n<th><strong>Aspect<br \/>\n<\/strong><\/th>\n<th>Biological Plant Protection Products<br \/>\n<small>(EU Regulation 1107\/2009)<br \/>\n<\/small><\/th>\n<th>Biostimulants<br \/>\n<small>(EU Regulation 2019\/1009)<\/small><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Product Purpose<br \/>\n<\/strong><\/td>\n<td>Direct control of pests, diseases, or weeds\n<\/td>\n<td>Stimulation of plant growth, improved nutrient uptake, etc.<\/td>\n<\/tr>\n<tr>\n<td><strong>Legal Category<br \/>\n<\/strong><\/td>\n<td>Plant protection product\n<\/td>\n<td>Fertilising product (functional category: biostimulant)<\/td>\n<\/tr>\n<tr>\n<td><strong>Required Evidence<br \/>\n<\/strong><\/td>\n<td>Efficacy trials, toxicology, ecotoxicology, residue analysis, etc.\n<\/td>\n<td>Functionality tests (e.g., improved yield, stress tolerance)<\/td>\n<\/tr>\n<tr>\n<td><strong>Scientific Evaluation<br \/>\n<\/strong><\/td>\n<td>EFSA + national authorities (harmonized procedure)\n<\/td>\n<td>Manufacturer self-declaration + compliance with technical requirements<\/td>\n<\/tr>\n<tr>\n<td><strong>Authorization<br \/>\n<\/strong><\/td>\n<td>Centralized or zonal (required before commercialization)\n<\/td>\n<td>Conformity assessment (notified body) + CE marking<\/td>\n<\/tr>\n<tr>\n<td><strong>Labeling and Permitted <em>Claims<br \/>\n<\/em><\/strong><\/td>\n<td>May include pest or disease control claims if approved\n<\/td>\n<td>Cannot include any <em>claims <\/em>related to pest or disease control<\/td>\n<\/tr>\n<tr>\n<td><strong>Permitted Microorganisms<br \/>\n<\/strong><\/td>\n<td>Only if evaluated and approved as an active substance\n<\/td>\n<td><i>Azotobacter <\/i>spp., <i>Rhizobium<\/i> spp., <i>Azospirillum <\/i>spp., mycorrhizal fungi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em><b>Figure 1.<\/b> Regulatory comparison between biological plant protection products and biostimulants under European legislation. Key differences include product purpose, evaluation and authorization requirements, and the permitted use of microorganisms. <\/em><\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c4df8d0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c4df8d0\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-389d557\" data-id=\"389d557\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-73e6fc9 elementor-widget elementor-widget-heading\" data-id=\"73e6fc9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"> Why is it crucial not to confuse them?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f1a1799 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"f1a1799\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The responsible use of agricultural products starts with understanding their legal and technical function. <strong>Only authorized biological plant protection products have scientifically proven their efficac<\/strong>y in controlling specific diseases or pests.&nbsp;<\/p><p>Using a biostimulant as if it were a plant protection product <strong>can pose both legal and agronomic risks<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-90cfdd0 elementor-widget elementor-widget-heading\" data-id=\"90cfdd0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2. What does it mean for a biological plant protection product to be effective?<br><br><\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b8b1076 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"b8b1076\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In agriculture,<strong> the efficacy of a biological plant protection<\/strong> product is not measured by marketing claims or anecdotal impressions, but by its proven ability<strong> to control a pest or disease<\/strong> under real field conditions.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f67ef24 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f67ef24\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-21fa146\" data-id=\"21fa146\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7366bca elementor-widget elementor-widget-image\" data-id=\"7366bca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2560\" height=\"1915\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1.png\" class=\"attachment-full size-full wp-image-26625\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1.png 2560w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1-768x575.png 768w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1-1536x1149.png 1536w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1-2048x1532.png 2048w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1-600x449.png 600w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-af5921d\" data-id=\"af5921d\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-13145f0 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"13145f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"\" data-start=\"0\" data-end=\"120\">According to the<strong data-start=\"9\" data-end=\"46\"> Diccionario de la lengua espa\u00f1ola <\/strong>of the <strong data-start=\"53\" data-end=\"85\">Royal Spanish Academy (RAE)<\/strong>, the definition of <strong data-start=\"104\" data-end=\"116\">efficacy<\/strong> is:<\/p><blockquote data-start=\"122\" data-end=\"232\"><p class=\"\" data-start=\"124\" data-end=\"232\"><strong data-start=\"124\" data-end=\"136\">Efficacy<\/strong><br data-start=\"136\" data-end=\"139\"><em data-start=\"141\" data-end=\"162\">From Latin efficacia. <\/em><br data-start=\"162\" data-end=\"165\" data-is-only-node=\"\"><strong data-start=\"167\" data-end=\"176\">1. f.<\/strong> The ability to achieve the desired or expected effect.<\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-a99cf3d elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"a99cf3d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>A product is considered <strong>effective <\/strong>when it achieves a significant reduction in:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-53b4601 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"53b4601\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-843e729\" data-id=\"843e729\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-84e3764 elementor-widget elementor-widget-heading\" data-id=\"84e3764\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">INCIDENCE<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff7bb58 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"ff7bb58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The <strong>incidence <\/strong>of the disease (number of affected plants).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09b7514 elementor-widget elementor-widget-image\" data-id=\"09b7514\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/dead.png\" class=\"attachment-large size-large wp-image-26649\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/dead.png 512w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/dead-300x300.png 300w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/dead-150x150.png 150w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/dead-100x100.png 100w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c3076c5\" data-id=\"c3076c5\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c4be3e2 elementor-widget elementor-widget-heading\" data-id=\"c4be3e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">SEVERITY<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c9a3795 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"c9a3795\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The <strong>severity<\/strong> of symptoms (extent of damage to the plants).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5e1eea elementor-widget elementor-widget-image\" data-id=\"f5e1eea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/analytics.png\" class=\"attachment-large size-large wp-image-26641\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/analytics.png 512w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/analytics-300x300.png 300w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/analytics-150x150.png 150w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/analytics-100x100.png 100w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-165490a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"165490a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>These metrics are always compared to an <b>untreated control group<\/b>, which serves as a reference to assess the actual effect of the product, as well as to <b>reference treatments<\/b>\u2014chemical or biological\u2014that are commercially available and commonly used to control the same pest or disease. <\/p><p>In most trials, <b>three different doses<\/b> of the product under study are typically evaluated. This allows for the analysis not only of its <b>efficacy <\/b>but also of the <b>efficiency <\/b>of each dose. The goal of this comparison is to <b>identify the most cost-effective dose<\/b>, prioritizing a solution that is both viable and profitable for the farmer. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3b5a3a elementor-widget elementor-widget-image\" data-id=\"c3b5a3a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/03\/10-out-of-11.png\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f71c8e elementor-widget elementor-widget-heading\" data-id=\"4f71c8e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">How Is Efficacy Measured? Official Field Trials <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-08eb7c0 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"08eb7c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>To validate a biological or conventional plant protection product, <strong>field efficacy trials<\/strong> are conducted in accordance with recognized standards, such as<strong> Good Experimental Practices (GEP)<\/strong>. These studies follow strict scientific and statistical criteria to ensure that the results: <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a15db91 elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"a15db91\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5938b1f\" data-id=\"5938b1f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9b5b052 elementor-widget elementor-widget-image\" data-id=\"9b5b052\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/note.png\" class=\"attachment-large size-large wp-image-26617\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/note.png 512w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/note-300x300.png 300w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/note-150x150.png 150w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/note-100x100.png 100w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-296facf\" data-id=\"296facf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c86cdfd elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"c86cdfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Are <strong>objective and reproducible.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e4968de elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e4968de\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-414a070\" data-id=\"414a070\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b8fa15d elementor-widget elementor-widget-image\" data-id=\"b8fa15d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/fields.png\" class=\"attachment-large size-large wp-image-26613\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/fields.png 512w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/fields-300x300.png 300w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/fields-150x150.png 150w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/fields-100x100.png 100w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c967870\" data-id=\"c967870\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9ceea6b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"9ceea6b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Under <strong>real agronomic conditions.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e1f5488 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e1f5488\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9e379c7\" data-id=\"9e379c7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c587e0f elementor-widget elementor-widget-image\" data-id=\"c587e0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/balance.png\" class=\"attachment-large size-large wp-image-26629\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/balance.png 512w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/balance-300x300.png 300w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/balance-150x150.png 150w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/balance-100x100.png 100w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e1f1467\" data-id=\"e1f1467\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b1b8542 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"b1b8542\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Allow for comparison<\/strong> with other available solutions.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-96ae50d elementor-widget elementor-widget-image\" data-id=\"96ae50d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1140\" height=\"397\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/essais-semences-antedis-155000-parcelles-en-2015-1140p.jpg\" class=\"attachment-full size-full wp-image-26637\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/essais-semences-antedis-155000-parcelles-en-2015-1140p.jpg 1140w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/essais-semences-antedis-155000-parcelles-en-2015-1140p-768x267.jpg 768w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/essais-semences-antedis-155000-parcelles-en-2015-1140p-600x209.jpg 600w\" sizes=\"(max-width: 1140px) 100vw, 1140px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><em><b>Picture 1.<\/b> Field Trial. The image shows the experimental plots. <b>Source<\/b>.  https:\/\/www.antedis.com\/<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ff9220d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ff9220d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b83a45e\" data-id=\"b83a45e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8a1fabf elementor-widget elementor-widget-heading\" data-id=\"8a1fabf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Common Efficacy Indicators:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1cda5fb elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"1cda5fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Phytotoxicity<\/strong>: Potential Adverse Effects<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c85aa14 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"c85aa14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Disease Index<\/strong>: % of Affected Plants<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a368a3 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"2a368a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Disease <strong>Incidence Reduction<\/strong> Compared to the Control<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-787ea13 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"787ea13\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Severity Reduction i<\/strong>n Visible Symptoms<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f91079 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"1f91079\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Yield<\/strong>: Production (Kg\/Ha), Quality <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c151466 elementor-widget elementor-widget-heading\" data-id=\"c151466\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Beyond Visual Perception:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-66e12e3 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"66e12e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>A product is not considered effective just because it &#8220;seems to work.&#8221; It must demonstrate, with <strong>solid data<\/strong>, that: <\/p><ol><li>The control is <strong>consistent<\/strong>.<\/li><li>The improvement is<strong> statistically significant.<\/strong><\/li><li>It can be successfully used into <strong>integrated pest and disease management strategies.<\/strong><\/li><\/ol><p>In summary, an <strong>effective biological plant protection product is not a promise, but a scientific guarantee based on evidence<\/strong>. That is why only authorized products that have undergone this process can offer trust and real results to the farmer. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bd072ac elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bd072ac\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-619f493\" data-id=\"619f493\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68f1741 elementor-widget elementor-widget-heading\" data-id=\"68f1741\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">3. How is a Biological Plant Protection Product Registered in Europe?<\/h3>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f9f86d4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f9f86d4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d87ef0f\" data-id=\"d87ef0f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f048083 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"f048083\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The<strong> registration of a biological plant protection product in the European Union<\/strong> is a rigorous technical and regulatory process that ensures only <strong>effective, safe, and sustainable solutions<\/strong> reach the agricultural market.<\/p><p>Unlike other inputs, these products must undergo thorough scientific evaluations that validate their efficacy against specific pests or diseases, as well as their safety for human health, the environment, and crops.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5760f38 elementor-widget elementor-widget-heading\" data-id=\"5760f38\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Step 1: Active Substance Evaluation<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09c6e10 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"09c6e10\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The first step is the approval of the <strong>active substance<\/strong> (e.g., a microorganism like<em> Trichoderma asperellum<\/em>) at the European level, in accordance with <strong>Regulation (EU) 1107\/2009<\/strong>. This evaluation is carried out by the <strong>EFSA (European Food Safety Authority)<\/strong> and member states, and focuses on: <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-46370af elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46370af\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-f05da8a\" data-id=\"f05da8a\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f94d27 elementor-widget elementor-widget-heading\" data-id=\"8f94d27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Toxicological and Ecotoxicological Profile<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9424ab elementor-widget elementor-widget-image\" data-id=\"b9424ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/planet-earth.png\" class=\"attachment-large size-large wp-image-26675\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/planet-earth.png 512w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/planet-earth-300x300.png 300w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/planet-earth-150x150.png 150w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/planet-earth-100x100.png 100w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-1d229df\" data-id=\"1d229df\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-1f697d6\" data-id=\"1f697d6\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f73532 elementor-widget elementor-widget-heading\" data-id=\"8f73532\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Stability and Mode of Action\u00a1<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dcf8beb elementor-widget elementor-widget-image\" data-id=\"dcf8beb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/chemistry.png\" class=\"attachment-large size-large wp-image-26679\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/chemistry.png 512w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/chemistry-300x300.png 300w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/chemistry-150x150.png 150w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/chemistry-100x100.png 100w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-879f845\" data-id=\"879f845\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-93afe46\" data-id=\"93afe46\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ad4ed81 elementor-widget elementor-widget-heading\" data-id=\"ad4ed81\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Absence of Unacceptable Risks<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d9aa25 elementor-widget elementor-widget-image\" data-id=\"0d9aa25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/no-entry.png\" class=\"attachment-large size-large wp-image-26683\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/no-entry.png 512w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/no-entry-300x300.png 300w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/no-entry-150x150.png 150w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/no-entry-100x100.png 100w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-48573ca elementor-widget elementor-widget-text-editor\" data-id=\"48573ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Important<\/strong>: This approval<strong> does not authorize direct commercial use<\/strong>. It only validates the active substance at the European level. <\/p><p>The next blog will cover this topic in depth.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91353c7 elementor-widget elementor-widget-heading\" data-id=\"91353c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Step 2: Formulated Product Evaluation<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9caa4b1 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"9caa4b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Once the active substance is approved, the efficacy of the <strong>formulated product<\/strong> containing it must be registered. This means efficacy studies must be conducted against each specific pathogen and crop. This process is carried out at the <strong>national or zonal level<\/strong>, depending on the country where the product is intended for commercialization. <\/p><p>A complete technica<strong>l dossier must be submitted<\/strong>, which includes:<\/p><ol><li><strong>Efficacy trials under real conditions<\/strong> (following GEP standards).<\/li><li><strong>Risk assessment<\/strong> for humans, beneficial fauna, and the environment.<\/li><li><strong>Residue studies<\/strong>, <strong>soil behavior<\/strong>, <strong>compatibilities<\/strong>, etc.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c57034c elementor-widget elementor-widget-heading\" data-id=\"c57034c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Climatic Zones and Zonal Evaluation:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-370ce4f elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"370ce4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"\" data-start=\"222\" data-end=\"617\">In order to adapt the evaluation of crop protection products to actual field use conditions, Europe has been divided into three major <strong data-start=\"363\" data-end=\"387\">agro-climatic zones<\/strong>, also known as <strong data-start=\"412\" data-end=\"437\">EPPO<\/strong><em data-start=\"439\" data-end=\"460\">Climatic Zones<\/em>. This division responds to the need to reflect variability in climate, crops and farming practices within the efficacy evaluation process.<\/p><p class=\"\" data-start=\"623\" data-end=\"664\">The three main zones defined are:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8ada11a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8ada11a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6e8c2fa\" data-id=\"6e8c2fa\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ec6fcc8 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"ec6fcc8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><style>\n .table-format {<br> width: 80%;<br> margin: 30px auto;<br> border-collapse: collapse;<br> text-align: center;<br>}<\/p>\n<p> .table-format th {<br> background-color: #e0f0e9;<br> color: #333;<br> padding: 12px;<br> font-weight: bold;<br> border: 1px solid #ccc;<br>}<\/p>\n<p> .table-format td {<br> padding: 10px;<br> border: 1px solid #ccc;<br>}<\/p>\n<p> .table-format tbody tr:nth-child(even) {<br> background-color: #f9f9f9;<br>}<br><\/style><\/p><table class=\"tabla-formato\"><thead><tr><th>Zone <\/th><th>Examples of Countries<\/th><th> Characteristics<\/th><\/tr><\/thead><tbody><tr><td>North<\/td> <td>Scandinavia, Baltic States, Ireland<\/td> <td>Cold climates, low disease pressure<\/td><\/tr><tr><td>Central Europe<\/td> <td>Germany, France, Netherlands, Poland&#8230;<\/td> <td>Temperate climate, both extensive and intensive crops<\/td><\/tr><tr><td>Southern Europe <\/td><td>Spain, Italy, Greece, Portugal<\/td> <td>Warm climates, high pest pressure, both intensive and extensive crops<\/td><\/tr><\/tbody><\/table>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-d7ad0b2\" data-id=\"d7ad0b2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a581bdc elementor-widget elementor-widget-image\" data-id=\"a581bdc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"733\" height=\"484\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/eppo-climat-zones-EU.jpg\" class=\"attachment-full size-full wp-image-26696\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/eppo-climat-zones-EU.jpg 733w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/eppo-climat-zones-EU-600x396.jpg 600w\" sizes=\"(max-width: 733px) 100vw, 733px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-8b7fe7a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"8b7fe7a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Each zone may have a <strong>zonal rapporteur member state (zRMS)<\/strong> that leads the evaluation. If the zRMS approves the product&#8217;s efficacy trials, other countries in the zone can accept it through <strong>mutual recognition.<\/strong> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b41f1cb elementor-widget elementor-widget-heading\" data-id=\"b41f1cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Summary of the Registration Process<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cf42a82 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"cf42a82\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<style>\n  .tabla-formato {\n    width: 80%;\n    margin: 30px auto;\n    border-collapse: collapse;\n    text-align: center;\n  }\n\n  .tabla-formato th {\n    background-color: #e0f0e9;\n    color: #333;\n    padding: 12px;\n    font-weight: bold;\n    border: 1px solid #ccc;\n  }\n\n  .tabla-formato td {\n    padding: 10px;\n    border: 1px solid #ccc;\n  }\n\n  .tabla-formato tbody tr:nth-child(even) {\n    background-color: #f9f9f9;\n  }\n<\/style>\n\n<table class=\"tabla-formato\">\n  <thead>\n    <tr>\n      <th>Stage\n<\/th><th>Level\n<\/th><th>Responsible\n<\/th><th>Objective<\/th>\n    <\/tr>\n  <\/thead>\n  <tbody>\n    <tr>\n      <td>Active Substance\n<\/td><td>European\n<\/td><td>EFSA + Member States\n<\/td><td>Approve the active substance<\/td>\n    <\/tr>\n    <tr>\n      <td>Formulated Product\n<\/td><td>National or Zonal\n<\/td><td>Member State \/ zRMS\n<\/td><td>Authorize commercial use<\/td>\n    <\/tr>\n    <tr>\n      <td>Final Authorization\n<\/td><td>Country by Country\n<\/td><td>National Authorities\n<\/td><td>Define crops, doses, conditions<\/td>\n    <\/tr>\n  <\/tbody>\n<\/table>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1affffa elementor-widget elementor-widget-heading\" data-id=\"1affffa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Why is this process important?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c2c178e elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"c2c178e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Because <strong>only a registered product can guarantee real results, safety and traceability<\/strong>. It is the only way to protect the farmer against non-validated solutions and ensure that the use of the product is: <\/p><ol><li>Effective against a specific pathogen, in the target crop and zone.<\/li><li>Compatible with the principles of sustainable agriculture.<\/li><li>Safe for the environment and the food chain.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8fdd625 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8fdd625\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-26f057f\" data-id=\"26f057f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ddc20e2 elementor-widget elementor-widget-heading\" data-id=\"ddc20e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">4. GEP Trials:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b742403 elementor-widget elementor-widget-heading\" data-id=\"b742403\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">The scientific basis of efficacy in biological plant protection products.<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e999519 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"e999519\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>When discussing the validation of a<strong> biological plant protection product,<\/strong> <strong>GEP (Good Experimental Practices) trials<\/strong> are the reference standard in Europe. They are essential to objectively and reproducibly demonstrate that the product truly works under agricultural use conditions. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d085727 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"d085727\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>GEP trials are field or greenhouse studies designed under strict scientific and regulatory criteria. They are regulated by European guidelines, such as those from <strong>EPPO (European and Mediterranean Plant Protection Organization)<\/strong>, and can only be conducted by <strong>authorized and accredited companies.<\/strong> <\/p><p>These studies allow for:<\/p><ol><li><strong>Measure the actual efficacy <\/strong>of a product against specific diseases or pests.<\/li><li>Compare it with reference products (chemical or biological).<\/li><li>Validate its use under different agronomic conditions.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12f0233 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"12f0233\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong data-start=\"53\" data-end=\"89\">GEP (<\/strong> <strong data-start=\"92\" data-end=\"127\">Good<\/strong><strong data-start=\"53\" data-end=\"89\">Experimental Practice)<\/strong><br data-start=\"127\" data-end=\"130\">A set of standards and guidelines that ensure the quality, reliability and reproducibility of efficacy trials of plant protection products. These tests must be performed following standardized protocols, under controlled conditions and with rigorous documentation, to ensure that the data generated are valid for the product registration process with the competent authorities.<\/p><p>In Europe, these practices are regulated under Directive<b> 91\/414\/EEC <\/b>and its updates, and they are a <b>mandatory requirement for the efficacy results to be accepted in the plant protection product authorization dossiers<\/b>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-48e94e4 elementor-widget elementor-widget-image\" data-id=\"48e94e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/field-of-grian.jpg\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><em><b>Image 1<\/b>. Field trial in experimental plots with different grain varieties.<br><b>Source<\/b>: SGS Field Studies<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db29d4d elementor-widget elementor-widget-heading\" data-id=\"db29d4d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">How are GEP Trials Designed?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f896c5 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"5f896c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<article class=\"text-token-text-primary w-full\" dir=\"auto\" data-testid=\"conversation-turn-30\" data-scroll-anchor=\"true\"><div class=\"text-base my-auto mx-auto py-5 [--thread-content-margin:--spacing(4)] @[37rem]:[--thread-content-margin:--spacing(6)] @[72rem]:[--thread-content-margin:--spacing(16)] px-(--thread-content-margin)\"><div class=\"[--thread-content-max-width:32rem] @[34rem]:[--thread-content-max-width:40rem] @[64rem]:[--thread-content-max-width:48rem] mx-auto flex max-w-(--thread-content-max-width) flex-1 text-base gap-4 md:gap-5 lg:gap-6 group\/turn-messages focus-visible:outline-hidden\" tabindex=\"-1\"><div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\"><div class=\"relative flex-col gap-1 md:gap-3\"><div class=\"flex max-w-full flex-col grow\"><div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"4972454c-9c75-4fa0-944d-5660bdf8243c\" data-message-model-slug=\"gpt-4o\"><div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\"><div class=\"markdown prose dark:prose-invert w-full break-words light\"><p class=\"\" data-start=\"0\" data-end=\"1012\">A properly executed GEP (Good Experimental Practice) trial is based on a rigorous experimental design that ensures the scientific validity of the results. This includes plots treated with different doses of the product under evaluation\u2014often three levels\u2014along with an untreated control group and reference treatments already authorized in the market, both chemical and biological. The goal is to determine the minimum effective dose with an optimal cost-benefit ratio.   <\/p><p class=\"\" data-start=\"0\" data-end=\"1012\">The experimental design must incorporate statistical principles such as randomization, replication, and appropriate statistical analysis to ensure the reproducibility and significance of the data. The entire process is thoroughly documented, covering everything from planting to harvest, with detailed records of crop development, disease incidence and severity, agronomic performance parameters, and any potential phytotoxic effects attributable to the treatment. <\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/article><ol><li><strong>Treated and untreated plots (control).<\/strong><\/li><li><strong>Variable doses <\/strong>to define the minimum effective dose.<\/li><li><strong>Reference treatments<\/strong> already authorized on the market.<\/li><li><strong>Robust statistical design:<\/strong> replication, randomization, and data analysis.<\/li><\/ol><p>GEP trials are the <strong>scientific evidence required by authorities<\/strong> to authorize a plant protection product. They ensure that: <\/p><ol><li><b>Efficacy is not anecdotal, but replicable.<\/b><\/li><li><b>The recommended dose is the most efficient from a technical, economic, and environmental perspective.<\/b><\/li><li><b>The product meets the quality and safety standards required in Europe.<\/b><\/li><\/ol><p>In conclusion, GEP trials<strong> are the guarantee that a biological plant protection product truly works<\/strong>. Without them, it is not possible to obtain official registration or offer security to the farmer. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2418184 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2418184\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-760f660\" data-id=\"760f660\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-55d4c11 elementor-widget elementor-widget-heading\" data-id=\"55d4c11\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">5. Efficacy and Efficiency in Plant Protection Products <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff8da3c elementor-widget elementor-widget-heading\" data-id=\"ff8da3c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">What do we mean by efficiency?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e2bf77 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"1e2bf77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>When evaluating a <strong>biological plant protection product<\/strong>, it is not enough to simply demonstrate that it is effective against a pest or disease. It must also be <strong>efficient<\/strong>: that is, it should provide a technically sound solution that is <strong>cost-effective for the farmer and environmentally friendly<\/strong>. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5cc3881 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5cc3881\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b78114b\" data-id=\"b78114b\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-16ff05f elementor-widget elementor-widget-image\" data-id=\"16ff05f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2560\" height=\"1915\" src=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1.png\" class=\"attachment-full size-full wp-image-26625\" alt=\"\" srcset=\"https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1.png 2560w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1-768x575.png 768w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1-1536x1149.png 1536w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1-2048x1532.png 2048w, https:\/\/biocontroltechnologies.com\/wp-content\/uploads\/2025\/05\/Logo-RAE-scaled-1-600x449.png 600w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7df647b\" data-id=\"7df647b\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-82b623d elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"82b623d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"\" data-start=\"0\" data-end=\"120\">According to the<strong data-start=\"9\" data-end=\"46\"> Diccionario de la lengua espa\u00f1ola <\/strong>by the<strong data-start=\"53\" data-end=\"85\"> Royal Spanish Academy (RAE)<\/strong>, the definition of <strong>efficiency <\/strong>is:<\/p><blockquote data-start=\"122\" data-end=\"232\"><p class=\"\" data-start=\"124\" data-end=\"232\"><strong data-start=\"316\" data-end=\"330\">efficiency<\/strong><br data-start=\"330\" data-end=\"333\">From lat. <em data-start=\"344\" data-end=\"357\">efficientia<\/em>.<br data-start=\"358\" data-end=\"361\" data-is-only-node=\"\">1.<strong data-start=\"363\" data-end=\"372\">f. The<\/strong> ability to dispose of someone or something to achieve a particular effect.<br data-start=\"453\" data-end=\"456\">2.<b><span data-start=\"458\" data-end=\"467\">f.<\/span> The ability to achieve the desired results with the minimum use of resources<\/b>.<\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-b286d90 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"b286d90\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>La <strong>eficiencia<\/strong> combina varios factores:<\/p><ol><li><strong>Minimum Effective Dose: <\/strong>The exact amount of product needed to achieve the desired level of control.<\/li><li><strong>Cost-Benefit Ratio<\/strong>: The treatment must justify its investment with measurable agronomic results (e.g., production, quality, plant health).<\/li><li><strong>Reduction of Environmental Impact:<\/strong> Avoiding overdosing, residues, and unnecessary risks to ecosystems.<\/li><\/ol><p>A product can be effective, but if it requires high doses or generates disproportionate costs, <strong>it will not be viable<\/strong> in professional agricultural practice.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8e965ee elementor-widget elementor-widget-heading\" data-id=\"8e965ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">How is efficiency measured in GEP trials?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c4e0c1 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"4c4e0c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>During <strong>efficacy trials<\/strong>, the following is also evaluated:<\/p><ol><li><strong>Crop Response<\/strong> to Different Doses<\/li><li><strong>Agricultural Yield <\/strong>(kg\/ha, commercial quality)<\/li><li><strong>Phytotoxicity <\/strong>or Potential Negative Effects of the Product<\/li><\/ol><p>This allows for the identification of:<\/p><ol><li>The <strong>optimal dose, <\/strong>with the best balance between efficacy, cost, and sustainability.<\/li><li><strong>The most appropriate application strategy <\/strong>(frequency, timing, compatibility with other products).<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-75f7802 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"75f7802\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-f8a3998\" data-id=\"f8a3998\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1b5efa5 elementor-flip-box--effect-push elementor-flip-box--direction-up elementor-widget elementor-widget-flip-box\" data-id=\"1b5efa5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"flip-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-flip-box\" tabindex=\"0\">\n\t\t\t<div class=\"elementor-flip-box__layer elementor-flip-box__front\">\n\t\t\t\t<div class=\"elementor-flip-box__layer__overlay\">\n\t\t\t\t\t<div class=\"elementor-flip-box__layer__inner\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-flip-box__layer__title\">\n\t\t\t\t\t\t\t\t1. Crop Response to Different Doses\t\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-flip-box__layer__description\">\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"elementor-flip-box__layer elementor-flip-box__back\">\n\t\t\t<div class=\"elementor-flip-box__layer__overlay\">\n\t\t\t\t<div class=\"elementor-flip-box__layer__inner\">\n\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-flip-box__layer__title\">\n\t\t\t\t\t\t\t1. Crop Response to Different Doses\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-flip-box__layer__description\">\n\t\t\t\t\t\t\t\nDetermining the crop's response to various doses of the product is fundamental to assessing its real efficiency. An efficient dose is one that achieves agronomic objectives (such as pest control or improvement in plant growth) using the smallest possible amount of product. Efficiency is clearly demonstrated when lower doses achieve the same or better results than higher doses, reducing costs, avoiding over-application, and contributing to more sustainable and economically viable agriculture.  \t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-6d9d4fc\" data-id=\"6d9d4fc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a894b12 elementor-flip-box--effect-push elementor-flip-box--direction-up elementor-widget elementor-widget-flip-box\" data-id=\"a894b12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"flip-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-flip-box\" tabindex=\"0\">\n\t\t\t<div class=\"elementor-flip-box__layer elementor-flip-box__front\">\n\t\t\t\t<div class=\"elementor-flip-box__layer__overlay\">\n\t\t\t\t\t<div class=\"elementor-flip-box__layer__inner\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-flip-box__layer__title\">\n\t\t\t\t\t\t\t\t2. Agricultural Yield\t\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-flip-box__layer__description\">\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"elementor-flip-box__layer elementor-flip-box__back\">\n\t\t\t<div class=\"elementor-flip-box__layer__overlay\">\n\t\t\t\t<div class=\"elementor-flip-box__layer__inner\">\n\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-flip-box__layer__title\">\n\t\t\t\t\t\t\t2. Agricultural Yield as a Key Indicator\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-flip-box__layer__description\">\n\t\t\t\t\t\t\t\nThe final agricultural yield, both in terms of quantity (kg\/ha) and commercial quality (size, uniformity, appearance, and post-harvest shelf life), is one of the main indicators of a product's efficiency. An efficient product is one that generates significant increases in crop yield compared to alternative or conventional treatments. Additionally, improvements in commercial quality raise the value of production, directly enhancing profitability for the farmer and making it more attractive to incorporate into production systems.  \t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-0a77457\" data-id=\"0a77457\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ad8c6ae elementor-flip-box--effect-slide elementor-flip-box--direction-up elementor-widget elementor-widget-flip-box\" data-id=\"ad8c6ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"flip-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-flip-box\" tabindex=\"0\">\n\t\t\t<div class=\"elementor-flip-box__layer elementor-flip-box__front\">\n\t\t\t\t<div class=\"elementor-flip-box__layer__overlay\">\n\t\t\t\t\t<div class=\"elementor-flip-box__layer__inner\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-flip-box__layer__title\">\n\t\t\t\t\t\t\t\t3. Evaluation of Phytotoxicity\t\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-flip-box__layer__description\">\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"elementor-flip-box__layer elementor-flip-box__back\">\n\t\t\t<div class=\"elementor-flip-box__layer__overlay\">\n\t\t\t\t<div class=\"elementor-flip-box__layer__inner\">\n\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-flip-box__layer__title\">\n\t\t\t\t\t\t\t3. Evaluation of Phytotoxicity and Absence of Negative Effects on the Crop\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-flip-box__layer__description\">\n\t\t\t\t\t\t\t\nThe absence of phytotoxicity or minimal phytotoxic effects is essential to ensure the overall efficiency of any plant protection product. An efficient product must act selectively on the desired targets (disease control, pest management, plant growth promotion) without causing adverse effects on the crop. Careful evaluation of phytotoxicity ensures that the benefits achieved are not countered by unnecessary damage, thereby ensuring a healthy and economically viable crop in the long term.  \t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-930431a elementor-widget elementor-widget-heading\" data-id=\"930431a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">6. Conclusions.<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0a2a260 elementor-widget elementor-widget-heading\" data-id=\"0a2a260\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Why Trust in Registered Biological Plant Protection Products is a Sound Strategic Decision<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4cb01c2 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"4cb01c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>European agriculture is undergoing a major transformation. Regulatory demands, consumer expectations, and environmental challenges require solutions that are both<strong> effective, safe, and sustainable<\/strong>. In this scenario, <strong>biological plant protection products<\/strong> are positioned as key tools, but only if they have been <strong>scientifically validated and authorized according to the current regulations.<\/strong>  <\/p><p>In a regulated, safe, and demanding agricultural context, <strong>biological plant protection products <\/strong>represent a key solution for achieving <strong>effective, safe, and sustainable plant protection<\/strong>. However, their real value is only confirmed once they have passed a rigorous technical and legal evaluation process. <\/p><p>This process includes <strong>efficacy trials under GEP standards,<\/strong> safety studies for the applicator, consumer, and the environment, and regulatory validation in accordance with <strong>Regulation (EU) 1107\/2009.<\/strong> All of this ensures that the product not only works effectively but does so with solid scientific backing and under real agricultural use conditions. <\/p><p>Opting for registered products means choosing <strong>validated tools<\/strong>, whose<strong> efficacy has been proven<\/strong>, whose <strong>optimal dose has been defined<\/strong>, and whose use is compatible with the professional farmer&#8217;s goals of profitability, traceability, and sustainability.<\/p><p>Therefore<strong>, trusting authorized biological plant protection products is not only a responsible choice but a professional strategy based on evidence.<\/strong> Because when a product is <strong>verified, validated, and proven<\/strong>, there\u2019s no doubt:<strong> it works.<\/strong> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Evaluating the Efficacy and Efficiency of Plant Protection Products: Key Factors for Assessing the Impact and Performance of Biological Crop Protection Inputs. Biological plant protection products, also known as biopesticides, are transforming modern agriculture by offering effective and sustainable solutions for pest and disease control. In response to the decreasing number of approved chemical active [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":26633,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1317,1335],"tags":[1242,912,913,914,915,916,917,758,918,816,919,920,921,922,923,924,925,926,719,927,928,930,828,1243,931,829,932,933],"class_list":["post-26773","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-eng","category-registration-and-authorization","tag-agricultura-sostenible-2-en","tag-agricultural-yield","tag-agroclimatic-zones","tag-biologic-plant-protection-products","tag-biopesticides","tag-biostimulants","tag-disease","tag-ecological-agriculture","tag-efficacy","tag-efficiency","tag-environmental-impact","tag-environmental-safety","tag-eppo-en","tag-eu-regulation-1107-2009","tag-european-regulation","tag-gep-trials","tag-integrated-pest-strategy","tag-minimum-effective-dose","tag-pest-control","tag-phytosanitary-registration","tag-phytotoxicity","tag-scientific-validation","tag-sustainability","tag-t34-biocontrol-en","tag-technical-evaluation","tag-traceability","tag-trichoderma-asperellum-en","tag-zero-residue"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Phytosanitary Registration Process: Assessing Effectiveness and Efficiency. Part I\/II | Biocontrol Technologies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biocontroltechnologies.com\/en\/2025\/05\/03\/the-phytosanitary-registration-process-assessing-effectiveness-and-efficiency-part-i-ii\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Phytosanitary Registration Process: Assessing Effectiveness and Efficiency. Part I\/II | Biocontrol Technologies\" \/>\n<meta property=\"og:description\" content=\"Evaluating the Efficacy and Efficiency of Plant Protection Products: Key Factors for Assessing the Impact and Performance of Biological Crop Protection Inputs. Biological plant protection products, also known as biopesticides, are transforming modern agriculture by offering effective and sustainable solutions for pest and disease control. 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